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>INVESTIGATOR SPONSORED STUDIES PROGRAM
Cephalon
Pipeline
A drug discovery program that is deep, purposeful and precise.
The Cephalon Oncology drug discovery program is delivering novel, cytotoxic, and molecular-targeted agents to treat numerous cancers.

Molecular-targeted agents

CEP-701 (lestaurtinib) FLT-3, TrkA, and JAK2/STAT protein tyrosine kinase inhibitor
In development for treatment of:
  • Acute myelogenous leukemia
  • Myeloproliferative disorders
CEP-11981 TIE-2/pan VEGFR kinase inhibitor
In development for treatment of:
  • Multiple solid and hematological tumors
CEP-18770 proteasome inhibitor
In development for treatment of:
  • Multiple myeloma
  • Lymphoma
  • Solid tumors
CEP-9722 PARP (poly (ADP-ribose) polymerase) inhibitor
In development for treatment of:
  • Breast and ovarian tumors
  • Radio- and chemo-sensitizer for resistant cancers
Cytotoxic agent

Bendamustine HCl
In development for treatment of:
  • Non-Hodgkin’s lymphoma
  • Chronic lymphocytic leukemia
  • Multiple myeloma
  • Small cell lung cancer
Novel agents

Anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) inhibitors
In development for treatment of:
  • Anaplastic large-cell lymphoma (ALCL)
  • Inflammatory myofibroblastic tumors (IMT)
  • Glioblastoma
cMET receptor tyrosine kinase (RTK) inhibitors
In development for treatment of:
  • Multiple myeloma
  • Multiple solid and hematologic cancers
  • Papillary renal carcinoma
  • Gastric cancer
  • Osteo- and soft-tissue sarcomas
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